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Article

Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis.

Journal of the National Cancer Institute - 1 Jul 2014

Guan Bin, Rahmanto Yohan Suryo, Wu Ren-Chin, Wang Yihong, Wang Zhong, Wang Tian-Li, Shih Ie-Ming

Abstract excerpt

The chromatin remodeling gene, ARID1A, has been implied as a tumor suppressor, and its somatic inactivating mutations occur in a wide variety of human cancers, most frequently in ovarian and uterine endometrioid and ovarian clear cell carcinomas. Tumors with ARID1A mutations also frequently harbor PTEN or PIK3CA mutations, suggesting their collaboration in tumorigenesis. Here, we used a conditional knockout mouse...

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Source

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Identifiers

PMID: 24899687
DOI: 10.1093/jnci/dju146
PMCID: PMC4056776

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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