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Article

Identification of pleiotropic genes between risk factors of stroke by multivariate metaCCA analysis.

Molecular genetics and genomics : MGG - 1 Sept 2020

Wang Zun, Greenbaum Jonathan, Qiu Chuan, Li Kelvin, Wang Qian, Tang Si-Yuan, Deng Hong-Wen

Abstract excerpt

Genome-wide association studies (GWASs) have identified more than 20 genetic loci as risk predictors associated with stroke. However, these studies were generally performed for single-trait and failed to consider the pleiotropic effects of these risk genes among the multiple risk factors for stroke. In this study, we applied a novel metaCCA method followed by gene-based VEGAS2 analysis to identify the risk genes...

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Identifiers

PMID: 32474671
DOI: 10.1007/s00438-020-01692-8
PMCID: PMC7394724

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