Article
Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Sept 2015
Hu Zhongyang, Liu Jia, Song Zhi, Hou Qiao, Fan Xuejun, Hou Deren
Abstract excerpt
BACKGROUND: Ischemic stroke (IS) is a multifactorial disease that displays a strong genetic predisposition. However, the genetic architecture of IS has yet to be fully elucidated. It was hypothesized that epistasis between genes in multiple atherothrombotic pathways may play a vital role in determining the susceptibility to IS. The aim of the present study was to investigate the contributions of the hypothesized...
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