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Article

Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2005

Liu Ying, Yao Zhi-Xing, Bendavid Claude, Borgmeyer Carol, Han Zeqiu, Cavalli Luciane R, Chan Wai-Yee, Folmer Janet, Zirkin Barry R, Haddad Bassem R, Gallicano G Ian, Papadopoulos Vassilios

Abstract excerpt

Cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) is critical in determining cortisol and sex steroid biosynthesis. To investigate how CYP17 functions in vivo, we generated mice with a targeted deletion of CYP17. Although in chimeric mice Leydig cell CYP17 mRNA and intratesticular and circulating testosterone levels were dramatically reduced (80%), the remaining testosterone was sufficient to support...

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Identifiers

PMID: 15890676
DOI: 10.1210/me.2004-0418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice.PMID 15890676Read ↗

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