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Article

Unveiling the interplay between mutational signatures and tumor microenvironment: a pan-cancer analysis.

Frontiers in immunology - 1 Jan 2023

Luo Li-Zhi, Li Sheng, Wei Chen, Ma Jiao, Qian Li-Mei, Chen Yan-Xing, Wang Shi-Xiang, Zhao Qi

Abstract excerpt

Background: While recent studies have separately explored mutational signatures and the tumor microenvironment (TME), there is limited research on the associations of both factors in a pan-cancer context. Materials and methods: We performed a pan-cancer analysis of over 8,000 tumor samples from The Cancer Genome Atlas (TCGA) project. Machine learning methods were employed to systematically explore the...

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Identifiers

PMID: 37283742
DOI: 10.3389/fimmu.2023.1186357
PMCID: PMC10239828

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