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Article

Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia.

Pediatric hematology and oncology - 1 Feb 2020

Akın-Balı Dilara Fatma, Aktas Sedef Hande, Unal Mehmet Altay, Kankılıc Teoman

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is a malignancy of lymphoid progenitor cells, characterized by a wide range of biological and clinical heterogeneity. Oxidative stress is a common problem observed in carcinogenesis and it is involved in developing treatment resistance. Nuclear Factor Erythroid-2-Like 2 (Nrf2) transcription factor is the main regulator of antioxidant responses. The levels of reactive oxygen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31661353
DOI: 10.1080/08880018.2019.1682090

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