An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes.

doi:10.1007/s00702-020-02206-x

Article

An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2020

Berking Ann-Cathrine, Thiel Christiane, Schiele Miriam A, Baumann Christian, Kalisch Raffael, Notzen Swantje, Zwanzger Peter, Pané-Farré Christiane A, Hamm Alfons, Alpers Georg W, Fydrich Thomas, Fehm Lydia, Gerlach Alexander L, Straube Benjamin, Kircher Tilo, Rief Winfried, Plag Jens, Ströhle Andreas, Lang Thomas, Wittchen Hans-Ulrich, Arolt Volker, Romanos Marcel, Pauli Paul, Reif Andreas, Deckert Jürgen, Domschke Katharina, Weber Heike

Abstract excerpt

While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation-DNA methyltransferases (DNMTs)-has yet to be investigated. In an effort to investigate DNMT genotype-specific effects on dimensional anxiety traits in addition to the categorical phenotype of panic disorder, 506 panic disorder patients and 3112 healthy...

Topics

Anxiety
Anxiety Disorders
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
DNA Methyltransferase 3A
Humans
Panic Disorder

An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes.

Abstract excerpt

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