Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations.

doi:10.1002/ajmg.b.32085

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Article

Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2012

Reif Andreas, Weber Heike, Domschke Katharina, Klauke Benedikt, Baumann Christian, Jacob Christian P, Ströhle Andreas, Gerlach Alexander L, Alpers Georg W, Pauli Paul, Hamm Alfons, Kircher Tilo, Arolt Volker, Wittchen Hans-Ulrich, Binder Elisabeth B, Erhardt Angelika, Deckert Jürgen

Abstract excerpt

Panic disorder (PD) is a common mental disorder, ranking highest among the anxiety disorders in terms of disease burden. The pathogenesis of PD is multifactorial with significant heritability, however only a few convincing risk genes have been reported thus far. One of the most promising candidates is the gene encoding monoamine oxidase A (MAOA), due to its key role in monoaminergic neurotransmission, established...

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PMID: 22911667
DOI: 10.1002/ajmg.b.32085

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MAOA

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