Article
Meta-analysis of genome-wide association studies of anxiety disorders.
Molecular psychiatry - 1 Oct 2016
Otowa T, Hek K, Lee M, Byrne E M, Mirza S S, Nivard M G, Bigdeli T, Aggen S H, Adkins D, Wolen A, Fanous A, Keller M C, Castelao E, Kutalik Z, Van der Auwera S, Homuth G, Nauck M, Teumer A, Milaneschi Y, Hottenga J-J, Direk N, Hofman A, Uitterlinden A, Mulder C L, Henders A K, Medland S E, Gordon S, Heath A C, Madden P A F, Pergadia M L, van der Most P J, Nolte I M, van Oort F V A, Hartman C A, Oldehinkel A J, Preisig M, Grabe H J, Middeldorp C M, Penninx B W J H, Boomsma D, Martin N G, Montgomery G, Maher B S, van den Oord E J, Wray N R, Tiemeier H, Hettema J M
Abstract excerpt
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic definitions based on clinical presentation, ADs likely represent various expressions of an underlying common diathesis of abnormal regulation of basic threat-response systems. We conducted genome-wide association analyses in nine...
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