Back to search

Article

HDAC4/5 regulate epidermal barrier function by modulating the epigenetic landscape of human keratinocytes

2026-08-14

Abstract excerpt

Keratinocyte proliferation and differentiation are essential to produce the stratified structure of the epidermis and maintain its barrier function. These processes are regulated by complex mechanisms including epigenetic regulation. In this study, we evaluated the role of HDAC4/5, two class IIa histone deacetylases, in the epigenetic regulation of proliferative and differentiated human keratinocytes using dedicat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
abb87513-71c5-57aa-896a-687a62e85209
DOI
10.64898/2026.08.13.741670
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
HDAC4/5 regulate epidermal barrier function by modulating the epigenetic landscape of human keratinocytesDOI 10.64898/2026.08.13.741670
Epigenetic Mechanisms of Epidermal DifferentiationSemantic proximity
Noval advance of histone modification in inflammatory skin diseases and related treatment methodsSemantic proximity
Epigenetics in Skin Homeostasis and AgeingSemantic proximity
Epigenetic‐modifying therapies: An emerging avenue for the treatment of inflammatory skin diseasesSemantic proximity
HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53Semantic proximity
Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblastsSemantic proximity
The Epigenetic Regulation of Wound HealingSemantic proximity
The Role of Keratinocytes in Skin Health and DiseaseSemantic proximity
Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In VivoSemantic proximity
Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermisSemantic proximity
The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and CancerSemantic proximity
Epigenetic Modulators in Anti-Aging Skincare: Unraveling Molecular Mechanisms and Advancing Patient ApplicationsSemantic proximity
Select a neighboring publication to make it the new centre.