Article
Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers
5 Aug 2022
Abstract excerpt
Microsatellite instability (MSI) has been identified in several tumors arising from either germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to immune checkpoint inhibitors (ICIs), particularly PD1/PD-L1 inhibitors. To date, the predictive role of MSI is currently used in the selection of colorectal cancer patients for immunotherapy; moreover, the expansion of clinical trials...
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