Article
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia.
Cancer cell - 9 Jan 2023
Loukas Ioannis, Simeoni Fabrizio, Milan Marta, Inglese Paolo, Patel Harshil, Goldstone Robert, East Philip, Strohbuecker Stephanie, Mitter Richard, Talsania Bhavik, Tang Wenhao, Ratcliffe Colin D H, Sahai Erik, Shahrezaei Vahid, Scaffidi Paola
Abstract excerpt
The evolution of established cancers is driven by selection of cells with enhanced fitness. Subclonal mutations in numerous epigenetic regulator genes are common across cancer types, yet their functional impact has been unclear. Here, we show that disruption of the epigenetic regulatory network increases the tolerance of cancer cells to unfavorable environments experienced within growing tumors by promoting the...
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