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Article

Effects of methylation of deiodinase 3 gene on gene expression and severity of Kashin-Beck disease.

Journal of cellular physiology - 1 Dec 2020

Li Zhaofang, Zhang Di, Li Qiang, Yang Xiaoli, Zhang Rongqiang, Zhang Dandan, Yang Xuena, Wang Chen, Tan Xiwang, Xiong Yongmin

Abstract excerpt

Kashin-Beck disease (KBD) is a complex endemic osteoarthropathy, which mainly occurs in the northeast to southwest China. Iodothyronine deiodinases 3 (DIO3) is one of the selenoproteins, which is closely related to bone metabolism and unclear to KBD. This study aims to investigate the role and associated mechanisms of methylation and expression of DIO3 with disease severity in patients with KBD. We performed a...

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PMID: 32458485
DOI: 10.1002/jcp.29809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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