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Article

Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

PloS one - 1 Jan 2013

Huang Lulin, Shi Yi, Lu Fang, Zheng Hong, Liu Xiaoqi, Gong Bo, Yang Jiyun, Lin Ying, Cheng Jing, Ma Shi, Lin He, Yang Zhenglin

Abstract excerpt

BACKGROUND: Kashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD. OBJECTIVE: To investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) with Kashin-Beck disease (KBD) in a Tibetan population and to investigate the association of these SNPs with the...

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Source

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Identifiers

PMID: 24058403
DOI: 10.1371/journal.pone.0071411
PMCID: PMC3751926

Genes

GPX1
DIO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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