ADH1B∗2 Is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption.

doi:10.1053/j.gastro.2020.05.054

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Article

ADH1B∗2 Is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption.

Gastroenterology - 1 Sept 2020

Vilar-Gomez Eduardo, Sookoian Silvia, Pirola Carlos Jose, Liang Tiebing, Gawrieh Samer, Cummings Oscar, Liu Wanqing, Chalasani Naga P

Abstract excerpt

BACKGROUND & AIMS: Alcohol dehydrogenase 1B (ADH1B) is involved in alcohol metabolism. The allele A (ADH1B∗2) of the rs1229984: A>G variant in ADH1B is associated with a higher alcohol metabolizing activity compared to the ancestral allele G (ADH1B∗1). Moderate alcohol consumption is associated with reduced severity of nonalcoholic fatty liver disease (NAFLD), based on histologic analysis, compared with no...

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PMID: 32454036
DOI: 10.1053/j.gastro.2020.05.054
PMCID: PMC7502531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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