Article
Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.
Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2011
Takeuchi Fumihiko, Isono Masato, Nabika Toru, Katsuya Tomohiro, Sugiyama Takao, Yamaguchi Shuhei, Kobayashi Shotai, Ogihara Toshio, Yamori Yukio, Fujioka Akihiro, Kato Norihiro
Abstract excerpt
BACKGROUND: Normative alcohol use (or drinking behavior) influences the risk of cardiovascular disease in a multi-faceted manner. To identify susceptibility gene variants for drinking behavior, a 2-staged genome-wide association study was performed in a Japanese population. METHODS AND RESULTS: In the stage-1 scan, 733 cases and 729 controls were genotyped with 456,827 SNP markers. The associated loci without...
Topics
Join the communities discussing this publication.