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Article

Mechanism of Color and Photoacidity Tuning for the Protonated Green Fluorescent Protein Chromophore.

Journal of the American Chemical Society - 24 Jun 2020

Lin Chi-Yun, Boxer Steven G

Abstract excerpt

The neutral or A state of the green fluorescent protein (GFP) chromophore is a remarkable example of a photoacid naturally embedded in the protein environment and accounts for the large Stokes shift of GFP in response to near UV excitation. Its color tuning mechanism has been largely overlooked, as it is less preferred for imaging applications than the redder anionic or B state. Past studies, based on...

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Identifiers

PMID: 32453950
DOI: 10.1021/jacs.0c02796
PMCID: PMC7485587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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