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Article

Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39.

BMC medical genetics - 27 Jun 2014

Melchiotti Rossella, Puan Kia Joo, Andiappan Anand Kumar, Poh Tuang Yeow, Starke Mireille, Zhuang Li, Petsch Kerstin, Lai Tuck Siong, Chew Fook Tim, Larbi Anis, Wang De Yun, Poidinger Michael, Rotzschke Olaf

Abstract excerpt

BACKGROUND: Extracellular ATP is a pro-inflammatory molecule released by damaged cells. Regulatory T cells (Treg) can suppress inflammation by hydrolysing this molecule via ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also termed as CD39. Multiple studies have reported differences in CD39+ Treg percentages in diseases such as multiple sclerosis, Hepatitis B and HIV-1. In addition, CD39 polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Intracellular Signaling Peptides and Proteins

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Share to Rhinitis, Allergic

Share to Rhinitis, Allergic, Perennial

Share to T-Lymphocytes, Regulatory

Source

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Identifiers

PMID: 24970562
DOI: 10.1186/1471-2350-15-73
PMCID: PMC4094447

Genes

ENTPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39.PMID 24970562Read ↗

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