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Article

Deciphering Sex-Specific Differentiation of Human Fetal Gonads: Insight From Experimental Models

2 Jun 2022

Abstract excerpt

Sex-specific gonadal differentiation is initiated by the expression of SRY in male foetuses. This promotes a signalling pathway directing testicular development, while in female foetuses the absence of SRY and expression of pro-ovarian factors promote ovarian development. Importantly, in addition to the initiation of a sex-specific signalling cascade the opposite pathway is simultaneously inhibited. The somatic...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 35721511
DOI: 10.3389/fcell.2022.902082

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