Endothelial nitric oxide synthase (NOS3) rs2070744 polymorphism and risk for multiple sclerosis.

doi:10.1007/s00702-020-02211-0

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Article

Endothelial nitric oxide synthase (NOS3) rs2070744 polymorphism and risk for multiple sclerosis.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Aug 2020

Agúndez José A G, García-Martín Elena, Rodríguez Christopher, Benito-León Julián, Millán-Pascual Jorge, Díaz-Sánchez María, Calleja Patricia, Turpín-Fenoll Laura, Alonso-Navarro Hortensia, García-Albea Esteban, Plaza-Nieto José Francisco, Jiménez-Jiménez Félix Javier

Abstract excerpt

The possible role of oxidative stress and nitric oxide (NO) in the pathogenesis of multiple sclerosis (MS) has been suggested by several neuropathological, biochemical, and experimental data. Because the single-nucleotide polymorphism (SNP) rs2070744 in the endothelial nitric oxide synthase (eNOS or NOS3) gene (chromosome 7q36.1) showed association with the risk for MS in Iranians, we attempted to replicate the...

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PMID: 32449012
DOI: 10.1007/s00702-020-02211-0

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