Article
Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility.
Atherosclerosis - 1 Feb 2012
Manso Helena, Krug Tiago, Sobral João, Albergaria Isabel, Gaspar Gisela, Ferro José M, Oliveira Sofia A, Vicente Astrid M
Abstract excerpt
OBJECTIVE: Animal studies have allowed important insights into the role of the nitric oxide synthase (NOS) enzymes in atherosclerosis and hypertension, as well as in stroke. In this study we tested the hypothesis that the NOS1 and NOS3 genes, respectively encoding neuronal NOS (nNOS) and endothelial NOS (eNOS), influence stroke susceptibility and outcome after a stroke event. METHODS: We conducted a case-control...
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