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Article

A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia.

Pediatric diabetes - 1 Nov 2020

Gomez-Lopera Natalia, Alfaro Juan-Manuel, Rodriguez Alejandra-Marcela, Ramirez Alex, Leal Suzanne M, Pineda-Trujillo Nicolas

Abstract excerpt

OBJECTIVES: RNASEH1 gene has recently been associated with type 1 diabetes (T1D) in Colombia. The purpose of this study was to fine mapping the putative functional variant in RNASEH1 and testing its interaction with HLA tagSNPs. METHODS: Two-hundred nuclear families with T1D were included in this study. Probands were tested for GAD65 and IA-2 autoantibodies. Genotyping was performed using 20 coding tagSNPs...

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PMID: 32447804
DOI: 10.1111/pedi.13057

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