Article
RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia.
Journal of endocrinological investigation - 1 Jul 2018
Pineda-Trujillo N, Rodríguez-Acevedo A, Rodríguez A, Ruíz-Linares A, Bedoya G, Rivera A, Alfaro J-M
Abstract excerpt
BACKGROUND: In a previous work, we found linkage and association of type 1 diabetes (T1D) to a 12 known gene region at chromosome 2p25 in Colombian families. Here, we present further work on this candidate region. MATERIALS AND METHODS: Seventeen SNPs located on the 12 candidate genes, in 100 familial trios set, were tested by ARMS-tetraprimer-PCR or PCR-RFLP. Five extra SNPs in the vicinity of rs10186193 were...
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