Article
Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium.
Stem cell research - 1 Jul 2020
Sawada Tomoyo, Benjamin Kynon J M, Brandtjen Anna C, Tietze Ethan, Allen Samuel J, Paquola Apuã C M, Kleinman Joel E, Hyde Thomas M, Erwin Jennifer A
Abstract excerpt
In this study, we established induced pluripotent stem (iPS) cell lines from postmortem dura-derived fibroblasts of four control individuals with low polygenic risk score for psychiatric disorders including schizophrenia and bipolar disorder. The fibroblasts were reprogrammed into iPS cells using episomal vectors carrying OCT3/4, SOX2, KLF4, L-Myc, LIN28 and shRNA-p53. All iPS cell lines showed the same genotype...
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