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Article

Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis.

Scientific reports - 22 May 2020

Tamaoki Junya, Takeuchi Miki, Abe Ryo, Kaneko Hiroshi, Wada Taeko, Hino Shinjiro, Nakao Mitsuyoshi, Furukawa Yusuke, Kobayashi Makoto

Abstract excerpt

LSD1/KDM1A is a widely conserved lysine-specific demethylase that removes methyl groups from methylated proteins, mainly histone H3. We previously isolated the zebrafish LSD1 gene and demonstrated that it is required for primitive hematopoiesis. Recently, a neuron-specific splicing variant of LSD1 was found in mammals and its specific functions and substrate specificities were reported. To our surprise, zebrafish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32444613
DOI: 10.1038/s41598-020-65428-9
PMCID: PMC7244555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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