Article

The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision

2021-01-14

Abstract excerpt

H3K4Me demethylase KDM1a/LSD1 is a therapeutic target for multiple diseases, including the β-globinopathies (sickle cell disease and β-thalassemia) since its inactivation has been shown to lead to robust induction of the fetal globin genes. Here we examined the consequences of conditional inactivation of Lsd1 in adult red blood cells using a new Gata1 creERT2 BAC transgene. Loss of Lsd1 activity in mice blocke...

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Literature Corpus work: 236f43ed-190c-5711-b0a7-287d5a959eb4
DOI: 10.1101/2021.01.13.426552

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