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Article

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation

29 Jul 2021

Abstract excerpt

Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a therapeutic target for multiple diseases, including for the potential treatment of β-globinopathies (sickle cell disease and β-thalassemia), because it is a component of γ-globin repressor complexes,...

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PMID: 34324630
DOI: 10.1182/blood.2021011682

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