Role of IRF5 in the pathogenesis of immunoglobulin-A vasculitis.

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Article

Role of IRF5 in the pathogenesis of immunoglobulin-A vasculitis.

Clinical and experimental rheumatology - 1 Jan 2000

Genre Fernanda, Remuzgo-Martínez Sara, Prieto-Peña Diana, Atienza-Mateo Belén, Pulito-Cueto Verónica, Llorca Javier, Sevilla-Pérez Belén, Ortego-Centeno Norberto, Lera-Gómez Leticia, Leonardo María Teresa, Peñalba Ana, Cabero María Jesús, Martín-Penagos Luis, Miranda-Filloy José A, Navas Parejo Antonio, Sánchez Pérez Javier, de Argila Diego, Rubio Esteban, León Luque Manuel, Blanco-Madrigal Juan María, Galíndez-Agirregoikoa Eva, Blanco Ricardo, Gualillo Oreste, Martín Javier, Castañeda Santos, González-Gay Miguel A, López-Mejías Raquel

Abstract excerpt

OBJECTIVES: Interferon regulatory factor 5 (IRF5) is a major regulator of type I interferon induction and is also critical to produce pro-inflammatory cytokines. An influence of IRF5 genetic variants on the increased risk of immune-mediated diseases has been described. Accordingly, we aimed to evaluate the implication of IRF5 in the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular...

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PMID: 32441646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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