Article
Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire tissue-resident memory like properties.
European journal of immunology - 1 Oct 2020
Mazzoni Alessio, Maggi Laura, Montaini Gianni, Ramazzotti Matteo, Capone Manuela, Vanni Anna, Locatello Luca Giovanni, Barra Giusi, De Palma Raffaele, Gallo Oreste, Cosmi Lorenzo, Liotta Francesco, Annunziato Francesco
Abstract excerpt
Tissue-resident memory (Trm) cells are specialized components of both CD4+ and CD8+ T cell subsets that persist in peripheral nonlymphoid tissues following infections and provide fast response in case of a secondary invasion by the same pathogen. Trm cells express the surface markers CD69, CD103, and the immune checkpoint molecule PD-1. Trm cells develop not only in the context of infections but also in tumors,...
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