Article
CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma.
Journal for immunotherapy of cancer - 1 Jan 2021
Lai Chester, Coltart George, Shapanis Andrew, Healy Conor, Alabdulkareem Ahmad, Selvendran Sara, Theaker Jeffrey, Sommerlad Matthew, Rose-Zerilli Matthew, Al-Shamkhani Aymen, Healy Eugene
Abstract excerpt
BACKGROUND: Tumor infiltrating lymphocytes play a key role in antitumor responses; however, while several memory T-cell subtypes have been reported in inflammatory and neoplastic conditions, the proportional representation of the different subsets of memory T cells and their functional significance in cancer is unclear. Keratinocyte skin cancer is one of the most common cancers globally, with cutaneous squamous...
Topics
- Antigens, CD
- CD8-Positive T-Lymphocytes
- Carcinoma, Squamous Cell
- Case-Control Studies
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Immunologic Memory
- Integrin alpha Chains
- Lymphocytes, Tumor-Infiltrating
- Phenotype
- Prognosis