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Article

Resident memory T cells, critical components in tumor immunology.

Journal for immunotherapy of cancer - 4 Sept 2018

Mami-Chouaib Fathia, Blanc Charlotte, Corgnac Stéphanie, Hans Sophie, Malenica Ines, Granier Clémence, Tihy Isabelle, Tartour Eric

Abstract excerpt

CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A recently identified subpopulation of memory CD8+ T cells, named tissue-resident memory T (TRM) cells, persists in peripheral tissues and does not recirculate. This T-cell subset is considered an independent memory T-cell lineage with a...

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Identifiers

PMID: 30180905
DOI: 10.1186/s40425-018-0399-6
PMCID: PMC6122734

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