Article

Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancer

2018-04-25

Abstract excerpt

Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis initiated by single cell epithelial to mesenchymal transition or cooperative cell migration (CCM). We identified novel regulatory cross-talks between Tcf21 and Slug in mediating phenotypic and migration plasticity in high-grade serous ovarian adenocarcinoma. Live imaging discerned CCM as being achieved either through rapid cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 132d2ce4-f911-58d0-971f-3bcfbcf964b5
DOI: 10.1101/307934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancerDOI 10.1101/307934Read

Tumoroid model recreates clinically relevant phenotypes of high grade serous ovarian cancer cells, carcinoma associated fibroblasts, and macrophages.Semantic proximity Read

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21Semantic proximity Read

A Computational Systems Biology Approach Identifies SLUG as a Mediator of Partial Epithelial-Mesenchymal Transition (EMT).Semantic proximity Read

A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition (EMT)Semantic proximity Read

Discrete Molecular Classes of Ovarian Cancer Suggestive of Unique Mechanisms of Transformation and MetastasesSemantic proximity Read

Cellular and molecular mechanisms of plasticity in cancer.Semantic proximity Read

High-grade serous ovarian cancer cell lines exhibit heterogeneous responses to growth factor stimulationSemantic proximity Read

Plasticity in cell migration modes across development, physiology, and diseaseSemantic proximity Read

Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancerSemantic proximity Read

Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous CarcinomaSemantic proximity Read

Glycosphingolipids are mediators of cancer plasticity through independent signaling pathwaysSemantic proximity Read

PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancerSemantic proximity Read