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Article

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

7 Mar 2018

Abstract excerpt

Abstract High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is invariably associated with poor patient survival. We demonstrate that stroma exerts a key function in mesenchymal HGSOC. We highlight stromal heterogeneity in HGSOC by identifying four subsets of carcinoma-associated fibroblasts (CAF-S1-4)....

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PMID: 29535360
DOI: 10.1038/s41467-018-03348-z

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