Article
Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh.
PLoS genetics - 1 Jan 2012
Pierce Brandon L, Kibriya Muhammad G, Tong Lin, Jasmine Farzana, Argos Maria, Roy Shantanu, Paul-Brutus Rachelle, Rahaman Ronald, Rakibuz-Zaman Muhammad, Parvez Faruque, Ahmed Alauddin, Quasem Iftekhar, Hore Samar K, Alam Shafiul, Islam Tariqul, Slavkovich Vesna, Gamble Mary V, Yunus Md, Rahman Mahfuzar, Baron John A, Graziano Joseph H, Ahsan Habibul
Abstract excerpt
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation is not well understood. Here, we have performed the first genome-wide association study (GWAS) of arsenic-related...
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