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Article

Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT.

PloS one - 1 Jan 2013

Engström Karin S, Hossain Mohammad Bakhtiar, Lauss Martin, Ahmed Sultan, Raqib Rubhana, Vahter Marie, Broberg Karin

Abstract excerpt

Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is the efficiency of arsenic metabolism. The efficiency, in turn, is associated with non-coding single nucleotide polymorphisms (SNPs) in the arsenic methyltransferase AS3MT on chromosome 10q24. However, the mechanism of action for these SNPs is not yet clarified. Here, we assessed the influence of genetic variation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23341986
DOI: 10.1371/journal.pone.0053732
PMCID: PMC3544896

Genes

CNNM2
CALHM2
TRIM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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