Article
Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid.
Scientific reports - 20 May 2020
Vallejos-Sánchez Katherine, Lopez Juan M, Antiparra Ricardo, Toscano Emily, Saavedra Harry, Kirwan Daniela E, Amzel L M, Gilman R H, Maruenda Helena, Sheen Patricia, Zimic Mirko
Abstract excerpt
Pyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment regimens. Approximately 50% of multidrug-resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are also PZA resistant. Despite the key role played by PZA, its mechanisms of action are not yet fully understood. It has been postulated that pyrazinoic acid (POA), the hydrolyzed product of PZA,...
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