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Article

Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC.

Mechanisms of ageing and development - 1 Jun 2020

Gross Alden L, Carlson Michelle C, Chu Nadia M, McAdams-DeMarco Mara A, Mungas Dan, Simonsick Eleanor M, Varadhan Ravi, Xue Qian-Li, Walston Jeremy, Bandeen-Roche Karen

Abstract excerpt

INTRODUCTION: Multifactorial biological processes underpin dysregulation over several individual physiological systems. However, it is challenging to characterize and model this multisystemic dysregulation and its relationship with individual physiologic systems. We operationalized a theory-driven measure of multisystem dysregulation and empirically tested for measurement differences by key characteristics....

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Identifiers

PMID: 32423871
DOI: 10.1016/j.mad.2020.111258
PMCID: PMC7375911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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