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Article

Thr90Ser Mutation in Antithrombin is Associated with Recurrent Thrombosis in a Heterozygous Carrier.

Thrombosis and haemostasis - 1 Jul 2020

Lu Yeling, Villoutreix Bruno O, Biswas Indranil, Ding Qiulan, Wang Xuefeng, Rezaie Alireza R

Abstract excerpt

Antithrombin (AT) is a serine protease inhibitor that regulates the activity of coagulation proteases of both intrinsic and extrinsic pathways. We identified an AT-deficient patient with a heterozygous Thr90Ser (T90S) mutation who experiences recurrent venous thrombosis. To understand the molecular basis of the clotting defect, we expressed AT-T90S in mammalian cells, purified it to homogeneity, and characterized...

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Identifiers

PMID: 32422680
DOI: 10.1055/s-0040-1710590
PMCID: PMC7444675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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