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Article

Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis.

Nature reviews. Cancer - 1 Jul 2020

Yamashita Masayuki, Dellorusso Paul V, Olson Oakley C, Passegué Emmanuelle

Abstract excerpt

Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages of blood and immune cells. The maintenance of blood homeostasis requires a dynamic response of HSCs to stress, and dysregulation of these adaptive-response mechanisms underlies the development of myeloid leukaemia. Leukaemogenesis often occurs in a stepwise manner, with genetic and epigenetic changes accumulating in...

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Source

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Identifiers

PMID: 32415283
DOI: 10.1038/s41568-020-0260-3
PMCID: PMC7658795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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