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Article

The evolution of leukaemia from pre-leukaemic and leukaemic stem cells.

Journal of internal medicine - 1 May 2021

Shlush L I, Feldman T

Abstract excerpt

Haematopoietic stem and progenitor cells (HSPCs) are defined as unspecialized cells that give rise to more differentiated cells. In a similar way, leukaemic stem and progenitor cells (LSPCs) are defined as unspecialized leukaemic cells, which can give rise to more differentiated cells. Leukaemic cells carry leukaemic mutations/variants and have clear differentiation abnormalities. Pre-leukaemic HSPCs (PreL-HSPCs)...

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Identifiers

PMID: 33511694
DOI: 10.1111/joim.13236

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