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The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies

19 Feb 2024

Abstract excerpt

Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism. However, the high self-renewal and longevity of HSCs predispose them to accumulate mutations. The acquired mutations drive preleukemic clonal hematopoiesis, which is frequent among elderly people. The preleukemic state, although often asymptomatic, increases the risk of blood cancers. Nevertheless, the direct role of...

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PMID: 38440231
DOI: 10.3389/fonc.2024.1308709

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