Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

doi:10.1073/pnas.1300398110

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Article

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2013

Serio Andrea, Bilican Bilada, Barmada Sami J, Ando Dale Michael, Zhao Chen, Siller Rick, Burr Karen, Haghi Ghazal, Story David, Nishimura Agnes Lumi, Carrasco Monica A, Phatnani Hemali P, Shum Carole, Wilmut Ian, Maniatis Tom, Shaw Christopher E, Finkbeiner Steven, Chandran Siddharthan

Abstract excerpt

Glial proliferation and activation are associated with disease progression in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia. In this study, we describe a unique platform to address the question of cell autonomy in transactive response DNA-binding protein (TDP-43) proteinopathies. We generated functional astroglia from human induced pluripotent stem cells carrying an ALS-causing TDP-43...

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PMID: 23401527
DOI: 10.1073/pnas.1300398110
PMCID: PMC3607024

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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