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Article

Novel PTCH1 and concurrent TP53 mutations in four patients with numerous non-syndromic basal cell carcinomas: The paradigm of oncogenic synergy.

Experimental dermatology - 1 May 2022

Dasgeb Bahar, Pajouhanfar Sara, Jazayeri Ali, Schoenberg Elizabeth, Kumar Gaurav, Fortina Paolo, Berger Adam C, Uitto Jouni

Abstract excerpt

There has been a significant increase in basal cell carcinoma (BCC) incidence, the most common cancer in humans and the age of presentation with the first diagnosis of BCC has decreased in past decades. In this study, we investigated the possibility of genetic markers that can lead to earlier and closer observation of patients at high risk for development of multiple BCCs. The overall goal is to decrease the...

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Share to Carcinogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 34862824
DOI: 10.1111/exd.14510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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