Article

In silico analysis of single nucleotide polymorphisms (SNPs) in human FOXC2 gene

2017-10-09

Abstract excerpt

<h4>Introduction: </h4> : Lymphedema is an abnormal accumulation of interstitial fluid, due to inefficient uptake and reduced flow, leading to swelling and disability, mostly in the extremities. Hereditary lymphedema usually occurs as an autosomal dominant trait with allelic heterogeneity. <h4>Methods: </h4> : We identified single nucleotide polymorphisms (SNPs) in the FOXC2 gene using dbSNP, analyzed their effec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5eb3a9d8-6f3e-56d4-ad8e-4f3c57f8af21
DOI: 10.12688/f1000research.10937.2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In silico analysis of single nucleotide polymorphisms (SNPs) in human FOXC2 geneDOI 10.12688/f1000research.10937.2Read

Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays.Semantic proximity Read

Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological CancerSemantic proximity Read

Genetic landscape of FOXC2 mutations in lymphedema-distichiasis syndrome: Different mechanism of pathogenicity for mutations in different domains.Semantic proximity Read

Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis.Semantic proximity Read

Two rare PROX1 variants in patients with lymphedema.Semantic proximity Read

GJC2 Missense Mutations Cause Human LymphedemaSemantic proximity Read

Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer.Semantic proximity Read

Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological Cancer.Semantic proximity Read

The genetics of idiopathic intracranial hypertension (IIH): Integration of population studies and clinical dataSemantic proximity Read

Digenic Inheritance of a FOXC2 Mutation and Two PIEZO1 Mutations Underlies Congenital Lymphedema in a Multigeneration Family.Semantic proximity Read

Mutations in the VEGFR3 Signaling Pathway Explain 36% of Familial LymphedemaSemantic proximity Read

Identification of nsSNPs of transcription factor E2F1 predisposing individuals to lung cancer and head and neck cancer.Semantic proximity Read