Article
Sputum Cell-Free DNA: Valued Surrogate Sample for Detection of EGFR Mutation in Patients with Advanced Lung Adenocarcinoma.
The Journal of molecular diagnostics : JMD - 1 Jul 2020
Wang Zheng, Zhang Lin, Li Lin, Li Xiaoguang, Xu Yan, Wang Mengzhao, Liang Li, Jiao Peng, Li Yuanming, He Shurong, Du Jun, He Lei, Tang Min, Sun Mingjun, Yang Li, Di Jing, Zhu Guanshan, Shi Hong, Liu Dongge
Abstract excerpt
Sputum is a common cytologic sample type, but its potential use in EGFR mutation detection in patients with lung cancer is not fully evaluated. This study established an improved sputum cell-free DNA (cfDNA) extraction method study and applied a super-amplification refractory mutation system to detect the EGFR mutation status in sputum cfDNA. The sputum sediments were used for cytology evaluation. The study...
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