Article
Sputum cell-free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR-TKIs.
Cancer medicine - 1 May 2021
Wang Zheng, Li Xiaoguang, Zhang Lin, Xu Yan, Wang Mengzhao, Liang Li, Jiao Peng, Li Yuanming, He Shurong, Du Jun, He Lei, Tang Min, Sun Mingjun, Yang Li, Di Jing, Zhu Guanshan, Li Lin, Liu Dongge
Abstract excerpt
BACKGROUND: Sputum cell-free DNA (cfDNA) is a valuable surrogate sample for assessing EGFR-sensitizing mutations in patients with advanced lung adenocarcinoma. Detecting EGFR exon 20 p.T790 M (p.T790 M) is much more challenging due to its limited availability in tumor tissues. Exploring sputum cfDNA as an alternative for liquid-based sample type in detecting p.T790 M requires potential improvement in clinical...
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