Article
Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jan 2021
Gong Yongfang, Li Dong, Li Lili, Yang Juan, Ding Hanyan, Zhang Chong, Wen Guanhua, Wu Chao, Fang Zhirui, Hou Shu, Yang Yan
Abstract excerpt
Smad3 phosphorylation is implicated in hepatic fibro-carcinogenesis. Moreover, Smad3 phospho-isoform pSmad3L and pSmad3C are reversible and antagonistic, and the balance could shift from carcinogenesis to tumor-suppression. pSmad3C has recently assigned to perform a preventative effect against primary liver injury. Salvianolic acid B (Sal B), a component derived from Salvia miltiorrhiza, is empirically used for...
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