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Article

Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development.

Molecular and cellular biology - 1 Aug 2001

Weinstein M, Monga S P, Liu Y, Brodie S G, Tang Y, Li C, Mishra L, Deng C X

Abstract excerpt

Smads serve as intracellular mediators of transforming growth factor beta (TGF-beta) signaling. After phosphorylation by activated type I TGF-beta receptors, Smad proteins translocate to the nucleus, where they serve as transcription factors and increase or decrease expression of TGF-beta target genes. Mice lacking one copy each of Smad2 and Smad3 suffered midgestation lethality due to liver hypoplasia and...

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Source

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Identifiers

PMID: 11438667
DOI: 10.1128/MCB.21.15.5122-5131.2001
PMCID: PMC87237

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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