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Feasibility of monitoring peripheral blood to detect emerging clones in children with acute lymphoblastic leukemia†.

Pediatric blood & cancer - 1 Jul 2020

Saliba Jason, Evensen Nikki A, Meyer Julia A, Newman Daniel, Nersting Jacob, Narang Sonali, Ma Xiaotu, Schmiegelow Kjeld, Carroll William L

Abstract excerpt

Relapse-enriched somatic variants drive drug resistance in childhood acute lymphoblastic leukemia. We used digital droplet-based polymerase chain reaction to establish whether relapse-enriched mutations in emerging subclones could be detected in peripheral blood samples before frank relapse. Although limitations in sensitivity for some probes hindered detection of certain variants, we successfully detected...

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PMID: 32391957
DOI: 10.1002/pbc.28306

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