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Article

Ultrasensitive mutation detection identifies rare residual cells causing acute myelogenous leukemia relapse.

The Journal of clinical investigation - 1 Sept 2017

Parkin Brian, Londoño-Joshi Angelina, Kang Qing, Tewari Muneesh, Rhim Andrew D, Malek Sami N

Abstract excerpt

Acute myelogenous leukemia (AML) frequently relapses after complete remission (CR), necessitating improved detection and phenotypic characterization of treatment-resistant residual disease. In this work, we have optimized droplet digital PCR to broadly measure mutated alleles of recurrently mutated genes in CR marrows of AML patients at levels as low as 0.002% variant allele frequency. Most gene mutations...

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Remission Induction
Anthracyclines
Bone Marrow
Cytarabine
Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm, Residual

Stem Cell Transplantation

Transplantation, Homologous

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Identifiers

PMID: 28825596
DOI: 10.1172/JCI91964
PMCID: PMC5669556

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